000			02020cam a2200205 i 4500
020			_a9781107170377 (hardback)
020			_a1107170370 (hardback)
082	0	0	_a576.507 _bAPP.G
245	0	0	_aGenome editing and engineering : _bfrom TALENs, ZFNs and CRISPRs to molecular surgery / _cedited by Krishnarao Appasani (GeneExpression Systems, Inc, Waltham, Massachusetts, USA), with a foreword by George M. Church (Harvard University Medical School, Boston, Massachusetts, USA).
260			_aUK; _bCambridge University Press; _c2018.
300			_axxix, 472 pages, 32 unnumbered pages of plates : _billustrations (some color) ;
504			_aIncludes bibliographical references and index.
520			_a"Genome Editing and Engineering From Talens, ZFNs and CRISPRs to Molecular Surgery Recent advances in genome editing techniques using endonucleases such as TALENs and CRISPRs, combined with genomic engineering technologies have opened up a wide range of opportunities from applications in basic disease biology research to potential new diagnostic tools and clinical applications This complete guide to endonuclease-based genomic engineering gives readers a thorough understanding of this rapidly expanding field. Chapters cover the discovery, basic science, and application of these techniques, focusing particularly on their potential application to the treatment of cancer, and cardiovascular and immunological disease. The final section discusses the legal and ethical issues which accompany the technology. Providing authoritative coverage of the potential that genome editing and engineer carry, this is an ideal reference for researchers and graduate students and those working in the biotechnology and pharmaceutical industries, as well as in a clinical setting"--
650	1	2	_aGene Editing
650	2	2	_aTranscription Activator-Like Effector Nucleases
650	2	2	_aZinc Fingers
650	2	2	_aClustered Regularly Interspaced Short Palindromic Repeats
700	1		_aAppasani, Krishnarao,
942			_cBK
999			_c584848 _d584848