000			01839nam a2200181Ia 4500
999			_c293792 _d293792
020			_a0471872512
082			_a 572.8015118 CLO-C
100			_a Peter Clote
245			_aComputational Molecular Biology
260			_a New York _b John Wiley & Sons _c2000
300			_a ix, 286 pages : illustrations ; 25 cm.
490			_a Wiley series in mathematical and computational biology.
505			_a 1. Molecular Biology. 1.1. Some Organic Chemistry. 1.2. Small Molecules. 1.3. Sugars. 1.4. Nucleic Acids. 1.5. Proteins. 1.6. From DNA to Proteins. 1.7. Exercises -- 2. Math Primer. 2.1. Probability. 2.2. Combinatorial Optimization. 2.3. Entropy and Applications to Molecular Biology. 2.4. Exercises. 2.5. Appendix: Modification of Bezout's Lemma -- 3. Sequence Alignment. 3.1. Motivating Example. 3.2. Scoring Matrices. 3.3. Global Pairwise Sequence Alignment. 3.4. Multiple Sequence Alignment. 3.5. Genomic Rearrangements. 3.6. Locating Cryptogenes and Guide RNA. 3.7. Expected Length of gRNA in Trypanosomes. 3.8. Exercises. 3.9. Appendix: Maximum-Likelihood Estimation for Pair Probabilities -- 4. All About Eve. 4.1. Introduction. 4.2. Rate of Evolutionary Change. 4.3. Clustering Methods. 4.4. Maximum Likelihood. 4.5. Quartet Puzzling. 4.6. Exercises -- 5. Hidden Markov Models. 5.1. Likelihood and Scoring a Model. 5.2. Re-estimation of Parameters. 5.3. Applications. 5.4. Exercises -- 6. Structure Prediction.
520			_a "Primarily aimed at advanced undergraduate and graduate students from bioinformatics, computer science, statistics, mathematics and the biological sciences, this text will also interest researchers from these fields."--Jacket.
650			_a Bioinformatics. Genetics -- Mathematical models. Molecular biology -- Mathematical models.
700			_aRolf Backofen
942			_cBK