000			01758nam a22001337a 4500
999			_c261261 _d261261
020			_a 9781621821816
082			_a571.74 SIG
100			_a Lewis C Cantley; Tony Hunter; Richard Sever; Jeremy W Thorner
245			_aSignal Transduction: Principles, Pathways, and Processes
260			_bCold Spring Harbor Laboratory Press _c2014
520			_aCells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex network of signal transduction pathways within the cell ensures that these signals are relayed to the correct molecular targets and that the cell responds appropriately. This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. Taking a novel approach, it first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function. The book is essential reading for students learning about signal transduction for the first time. It will also be a vital reference for all cell, molecular, and developmental biologists and pharmacologists, neurobiologists, and immunologists studying processes regulated by cell signaling.
650			_a Cellular signal transduction. Developmental biology. Pathology, Molecular.
942			_cBK