000			01207cam a22001938i 4500
999			_c223154 _d223154
020			_a9781439837177 (pbk : alk. paper)
020			_a9781138490116 (hbk : alk. paper)
082	0	0	_a570.113 _bALO.A
100	1		_aAlon, Uri,
245	1	3	_aAn introduction to systems biology : _bdesign principles of biological circuits / _cUri Alon.
250			_aSecond edition.
300			_a324pages cm
504			_aIncludes bibliographical references and index.
505	0		_aPart one: Network motifs -- Transcription networks basic concepts -- Autoregulation -- The feed forward loop -- Temporal programs and the global structure of transcription networks -- Positive feedback, bistability and memory -- How to build a biological oscillator -- Robustness -- Kinetic proofreading and conformational proofreading -- Part two: Robust signalling -- Chemotaxis -- Fold-change detection -- Dynamical compensation and mutal resistance in tissues -- Robust spatial patterning in development -- Part three: Optimality -- Optimal gene circuit design -- Multi-objective optimality in biology -- Modularity.
650		0	_aSystems biology.
650		0	_aComputational biology.
650		0	_aBiological systems
942			_cBK