Part I: Essential pathology -- mechanisms of disease: Molecular mechanisms of cell death -- Acute and chronic inflammation -- Infection and host response -- Neoplasia -- Part II: Concepts in molecular biology and genetics: Basic concepts in human molecular genetics -- The human genome: implications for the understanding of human disease -- The human transcriptome: implications for the understanding of human disease -- The human epigenome: implications for the understanding of human disease -- The human proteome: implications for the understanding of human disease -- Integrative systems biology: implications for the understanding of human disease -- Part III: Principles and practice of molecular pathology: Pathology: the clinical description of human disease -- Molecular pathogenesis: the biological basis of human disease -- Integration of molecular and cellular pathogenesis -- Part IV: molecular pathology of human disease: Molecular basis of cardiovascular disease -- Molecular basis of hemostatic and thrombotic diseases -- Molecular basis of lymphoid and myeloid diseases -- Molecular basis of diseases of immunity -- Molecular basis of pulmonary disease -- Molecular basis of diseases of the gastrointestinal tract -- Molecular basis of liver disease -- Molecular basis of diseases of the exocrine pancreas -- Molecular basis of diseases of the endocrine system -- Molecular basis of gynecologic diseases -- Molecular basis of prostate disease -- Molecular basis of breast disease -- Molecular basis of skin disease -- Molecular basis of diseases of the nervous system -- Part V: Practice of molecular medicine: Molecular diagnosis of human disease -- Molecular assessment of human disease in the clinical laboratory -- Pharmacogenomics and personalized medicine in the treatment of human disease.

Medical textbook that offers uniquely broad coverage of the molecular basis of major human diseases in the context of traditional pathology, with implications for translational molecular medicine.