Indian science has come a long way from the sculpture of the bronze dancer and the advanced urbanization found in the Indus Valley Civilization to the exploration of the surface of the moon. Today, India is famous all over the world due to ISRO, DRDO, IT sectors, but ancient India was also advanced from the point of view of science and technology. India has achieved significant achievements in the fields of Mathematics, Physics, and Medicine in ancient India. Indus Valley Civilization was a business-oriented civilization. Therefore, weighing systems were developed there. According to archaeologists, in the Indus Valley Civilization, a system of scale ratio of 16 was developed. The Yajurveda describes numbers up to 10 Kharab. The most prevalent number of the decimal system (0 to 9) in the present world was invented in India. The description of the innumerable (Infinity) is firstly found In the Jain text "Anuyogdwar" Geometry is described in Vedang literature. The knowledge of the description of trigonometry in Varahamihira's 'Surya Siddhanta' (sixth century), Brahmagupta also provided sufficient information on trigonometry and he also constructed a sine table. Famous mathematicians like Aryabhata, Brahmagupta, Bhaskaracharya, Sridharacharya, etc. also had great proficiency in algebra. The work reveals an inner consistency by examining the entire science and technology development in ancient India.