TY - BOOK AU - Grand,R.J.A. AU - Reynolds,John J. TI - DNA repair and replication: mechanisms and clinical significance SN - 9780815345992 (pbk. : alk. paper) U1 - 572.8 PY - 2019/// CY - Florida PB - CRC Press KW - DNA Repair KW - DNA Replication KW - Genomic Instability KW - Molecular Targeted Therapy N1 - "A Garland Science book."; Includes bibliographical references; DNA replication and cell cycle control / Sara Priego Moreno, Rebecca M. Jones, and Agnieszka Gambus -- DNA replication termination and genomic instability / Rebecca M. Jones, Sara Priego Moreno, and Agnieszka Gambus -- Mechanisms of DNA damage tolerance / Anastasia Zlatanou and Cyrus Vaziri -- Repair of DNA adducts and single strand breaks / Alicja Winczura and John J Reynolds -- Homologous recombination at replication forks / Eva Petermann -- Mechanisms of double strand break repair by non-homologous end-joining / Michal Malewicz -- Protein methylation and the DNA damage response / Martin Higgs and Clare Davies -- Ubiquitin, SUMO, and the DNA double strand break response / R.M. Densham, A.J. Garvin, and J.R. Morris -- Transcription in the context of genome stability maintenance / Marco Saponaro -- RNA binding proteins and the DNA damage response / Roger Grand -- DNA replication and inherited human disease / John J. Reynolds and Grant S. Stewart -- Genetics of ataxia telangiectasia and AT like disorders / A. Malcolm R. Taylor -- DNA repair mechanisms in stem cells and its implications during ageing / Rachel Bayley and Paloma Garcia -- Targeting replication stress in sporadic tumours / Marwan Kwok and Tatjana Stankovik ER -