Includes bibliographical references and index.

Sequence databases / Rolf Apweiler -- Mapping databases / Tara Matise and Peter S. White -- Information retrieval from biological databases / Andreas D. Baxevanis -- Genomic databases / Tyra Wolfsberg -- Predictive methods using DNA sequences / Roderic Guigó and Enrique Blanco -- Predictive methods using RNA sequences / Michael Zucker and David Mathews -- Sequence polymorphisms / James C. Mullikin and Stephen T. Sherry -- Predictive methods using protein sequences / Burkhard Rost and Yanay Ofran -- Protein structure prediction and analysis / David Wishart -- Intermolecular interactions and biological pathways / Gary D. Bader and Anton J. Enright -- Assessing pairwise sequence similarity: blast and fasta / Andreas D. Baxevanis -- Creation and analysis of protein multiple sequence alignments / Geoffrey J. Barton -- Sequence assembly and finishing methods / Gerard Bouffard, Nancy F. Hansen, and Pamela Jacques Thomas -- Phylogenetic analysis / Fiona S.L. Brinkman -- Computational approaches in comparative genomics / Andreas D. Baxevanis -- Microarray analysis / John Quackenbush -- Proteomics and protein identification / Michael Giddings, Mark R. Holmes, and Kevin Ramkissoon -- Using perl to facilitate biological analysis / Lincoln D. Stein.

This edition provides tools and databases used in bioinformatics, loosely defined as the intersection of molecular and computational biology. With the goal of helping the reader design and implement a successful sequence analysis strategy, topics covered include: using software and Internet resources, submitting DNA sequences to databases, information retrieval from databases, phylogenetic analysis, a database for genome information called ACeDB, and practical aspects of multiple sequence alignment.