Statistical issues in drug development / by Stephen Senn
Material type:![Text](/opac-tmpl/lib/famfamfam/BK.png)
- 9780470018774 (cloth : alk. paper)
- 0470018771 (cloth : alk. paper)
- 615/.190727 SEN
Item type | Current library | Home library | Call number | Status | Date due | Barcode | |
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Dept. of Statistics Processing Center | Dept. of Statistics | 615.190727 SEN (Browse shelf(Opens below)) | Available | STA9481 |
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Includes bibliographical references and index.
A brief and superficial history of statistics for drug developers -- Design and interpretation of clinical trials as seen by a statistician -- Probability, Bayes, P-values, tests of hypotheses, and confidence intervals -- The work of the pharmaceutical statistician -- Allocating treatments to patients in clinical trials -- Baselines and covariate information --
The measurement of treatment effects -- Demographic subgroups : representation and analysis -- Multiplicity -- Intention to treat, missing data and related matters -- One-sided and two-sided tests and other issues to do with significance and P-values -- Determining the sample size -- Multicentre trials -- Active control equivalence studies --
Meta-analysis -- Cross-over trials -- n-of-1 trials -- Sequential trials -- Dose-finding -- Concerning pharmacokinetics and pharmacodynamics -- Bioequivalence studies -- Safety data, harms, drug monitoring, and pharmaco-epidemiology -- Pharmaco-economics and portfolio management -- Concerning pharmacogenetics, pharmacogenomics, and related matters.
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