Discovering Retroviruses: Beacons in the Biosphere
Material type: TextPublication details: Cambridge, Massachusetts Harvard University Press 2018Description: xi, 177 pages : color illustrations, color map ; 24 cmISBN:- 9780674971707
- 579.2569 SKA-D
Item type | Current library | Home library | Call number | Status | Date due | Barcode | |
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Book | Dept. of Computational Biology and Bioinformatics Processing Center | Dept. of Computational Biology and Bioinformatics | 579.2569 SKA-D (Browse shelf(Opens below)) | Available | DCB3580 |
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579.17 MON-A .PS The Amoeba in the Room: Lives of the Microbes | 579.2 PHO-M Molecular and cellular biology of viruses | 579.2 STR Structure based Study of Viral Replication | 579.2569 SKA-D Discovering Retroviruses: Beacons in the Biosphere | 579.3078 DAS-M Microbial Biotechnology Manual for Bacterial systems | 579.323 HEL Helicobacter pylori research : From Bench to Bedside | 579.342 ZIM-M .PS Microcosm: E-coli and The New Science of Life |
Introduction -- Early pioneers -- Amending the central dogma -- The origin of retroviruses -- Retroviruses and evolution -- Revealing the genetic basis of cancer -- HIV and the AIDS pandemic -- Epilogue.
When invading a host cell, viruses seize cell machinery to make copies of their own genes. The immune system recognizes the invasion. In contrast, retroviruses colonize host cells through the process of reverse transcriptase. Retroviruses open host cell DNA and graft in their retroviral RNA, integrating into the host genome. The immune system has difficulty recognizing or ridding of foreign DNA that has become its own. Discovering Retroviruses presents the history of retrovirus discovery. Skalka illuminates retroviruses' role in evolution, human health, and disease, from the first sighting at the end of the nineteenth century to recent use in genetic engineering. Retroviral sequences in the human genome mark sites where endogenous retrovirus integrated over six million years ago. The 100,000 pieces of retrovirus DNA are remnants from germ line cell invasions and total approximately eight percent of the human genome. Through investigation of animal and human retroviral sequences, we know retroviral mutations can lead to cancers and immunodeficiencies, including HIV and leukemia. Today, researchers harness retroviruses for use in gene delivery systems and precision medicine advances. Discovering Retroviruses offers a lively perspective on stories of the major pioneers of the past century and the extraordinary roads to their discoveries, and demonstrates the growing importance of genetics to modern biomedicine.
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