The biology and genetics of cells and organisms -- The nature of cancer -- Tumor viruses -- Cellular oncogenes -- Growth factors, receptors, and cancer -- Cytoplasmic signaling circuitry programs many of the traits of cancer -- Tumor suppressor genes -- Prb and control of the cell cycle clock -- P53 and apoptosis: master guardian and executioner -- Eternal life : cell immortalization and tumorigenesis -- Multi-step tumorigenesis -- Maintenance of genomic integrity and the development of cancer -- Dialogue replaces monologue : heterotypic interactions and the biology of angiogenesis -- Moving out : invasion and metastasis -- Crowd control : tumor immunology and immunotherapy -- The rational treatment of cancer.

Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world.The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.The new Second Edition has been comprehensively revised and updated to include major advances in cancer biology over the past six years. Updates include current information on: The tumor microenvironment Metastatic dissemination Tumor immunology Cancer stem cells The epithelial-mesenchymal transition Multi-step tumorigenesis Invasion and metastasis Mutation of cancer cell genomes Greatly expanded treatment of traditional therapy Epigenetic contributions MicroRNA involvement The Warburg effectBesides its value as a textbook, The Biology of Cancer is a useful reference for individuals working in biomedical laboratories and for clinical professionals.