The success of individualized medicine, advanced crops, and new and sustainable energy sources requires thoroughly annotated genomic information and the integration of this information into a coherent model. A thorough overview of this field, Genome Annotation explores automated genome analysis and annotation from its origins to the challenges of next-generation sequencing data analysis. The book initially takes you through the last 16 years since the sequencing of the first complete microbial genome. It explains how current analysis strategies were developed, including sequencing strategies, statistical models, and early annotation systems. The authors then present visualization techniques for displaying integrated results as well as state-of-the-art annotation tools, including MAGPIE, Ensembl, Bluejay, and Galaxy. They also discuss the pipelines for the analysis and annotation of complex, next-generation DNA sequencing data. Each chapter includes references and pointers to relevant tools.

DNA Sequencing Strategies -- Coding Sequence Prediction -- Between the Genes -- Genome-Associated Data -- Characterization of Gene Function through Bioinformatics: The Early Days -- Visualization Techniques and Tools for Genomic Data -- Automated Annotation Systems -- Dynamic Annotation Systems: End-User-Driven Annotation and Visualization -- Web-Based Workflows -- Analysis Pipelines for Next-Generation Sequencing Data.