Protein-protein complexes / Gopichandran Sowmya [and others] -- Prediction of highly-connected hubs in protein interaction networks by QSAR and biological data descriptors / Michael Hsing, Kendall Byler, Artem Cherkasov -- Protein oligomerization and gene fusion in cancer / Ju Lin Tan, Gopichandran Sowmya, Pandjassarame Kangueane -- Immunological protein-protein interactions : a critical reflection / Darren Flower -- Databases and methods for protein-protein/peptide interactions / Venkatarajan Subramanian Mathura [and others] -- Interface roughness in heteromeric obligate and non-obligate protein-protein complexes / Indrani Bera, Somak Ray -- NASCENT : an automatic protein interaction network generation tool for non-model organisms / Daniel Banky, Rafael Ordog, Vince Grolmusz -- PINAT1.0 : protein interaction network analysis tool / Sandeep K. Kushwaha, Madhvi Shakya -- Folding and binding of homodimers / Gopichandran Sowmya [and others] -- Molecular dynamics in PPI (unfused) and fused homologous proteins / Yu Yiting, Meena Kishore Sakharkar, Pandjassarame Kangueane -- Interface hot spots in protein complexes / Lei Li [and others] -- Protein-protein interfaces in cholera toxin complex / Gunasagaran Shamini, Manickam Ravichandran, Pandjassarame Kangueane -- TAQ DNA polymerase interactions with dna and fab / Nalayini Subramaniam, Pattabiraman Lalitha, Pandjassarame Kangueane -- Evolutionary dynamics at protein-protein interfaces of legume lectins / Lakshmipuram Seshadri Swapna, Bernard Offmann, Narayanaswamy Srinivasan -- Protein-protein and protein-lipid interactions in immune cell signaling / Amudhala Karthik [and others].

This book describes the fundamental physical, chemical, molecular and biological aspects of proteins binding to one another in cellular biology. PPI is a common phenomenon in cell and molecular biology events. The networks of PPI describe cellular function in both unicellular and multi-cellular organisms. Homo complexes (dimers of identical monomers) or hetero complexes (dimers of non-identical monomers) are involved in PPI. These complexes are common in catalysis, regulation and structural assembly. However, the molecular principles of protein interactions are difficult to understand due to the geometrical and chemical characteristics of proteins. The challenge today is to identify interaction partners and sites from sequence and/or structures. This book describes the principles (physics and chemistry) of PPI and protein interfaces to develop models for PPI predictions.