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Natural Product Chemistry for Drug Discovery

By: Contributor(s): Material type: TextTextPublication details: Cambridge Royal Society of Chemistry 2010Description: xvii, 440 p. : ill ; 24 cmISBN:
  • 9780854041930
Subject(s): DDC classification:
  • 615.19 NAT
Contents:
Natural products as drugs and leads to drugs: The historical perspective / David J. Newman and Gordon M. Cragg -- Chemical space and the difference between natural products and synthetics / Sheo B. Singh and J. Chris Culberson -- Mechanism of action studies / James J. La Clair -- The convention on biological diversity and its impact on natural product research / Geoffrey A. Cordell -- Plants: Revamping the oldest source of medicines with modern science / Giovanni Appendino and Federica Pollastro -- Macromarines: A selective account of the potential of marine sponges, molluscs, soft corals and tunicates as a source of therapeutically important molecular structures / Jennifer Carroll and Phillip Crews -- Microorganisms: Their role in the discovery and development of medicines / Cedric Pearce, Peter Eckard, Iris Gruen-Wollny and Friedrich G. Hansske -- Advances in biological screening for lead discovery / Christian N. Parker, Johannes Ottl, Daniela Gabriel and Ji-Hu Zhang -- Advances in instrumentation, automation, dereplication and prefractionation / Tim S. Bugni, Mary Kay Harper, Malcolm W.B. McCulloch and Emily L. Whitson -- Natural product combinatorial biosynthesis: Promises and realities / Daniel W. Udwary -- A snapshot of natural product-derived compounds in late stage clinical development at the end of 2008 / Mark S. Butler -- From natural product to clinical trials: NPI-0052 (Salinosporamide A), a marine actinomycete-derived -- anticancer agent / Kin S. Lam, G. Kenneth Lloyd, Saskia T.C. Neuteboom, Michael A. Palladino, Kobi M. Sethna, Matthew A. Spear and Barbara C. Potts -- From natural product to clinical trials: Bevirimat, a plant-derived anti-AIDS drug / Keduo Qian, Theodore J. Nitz, Donglei Yu, Graham P. Allaway, Susan L. Morris-Natschke and Kuo-Hsiung Lee -- Daptomycin / Richard H. Baltz -- Micafungin / Akihiko Fujie, Shuichi Tawara and Seiji Hashimoto.
Summary: Natural Product Chemistry for Drug Discovery provides a comprehensive summary of where natural product chemistry is today in drug discovery. The book covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products. Natural products are once again considered important tools in the drug discovery toolbox. The authors are all experts in their respective fields of natural product chemistry.
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Book Book Dept. of Computational Biology and Bioinformatics Processing Center Dept. of Computational Biology and Bioinformatics 615.19 NAT (Browse shelf(Opens below)) Available DCB1898

Natural products as drugs and leads to drugs: The historical perspective / David J. Newman and Gordon M. Cragg -- Chemical space and the difference between natural products and synthetics / Sheo B. Singh and J. Chris Culberson -- Mechanism of action studies / James J. La Clair -- The convention on biological diversity and its impact on natural product research / Geoffrey A. Cordell -- Plants: Revamping the oldest source of medicines with modern science / Giovanni Appendino and Federica Pollastro -- Macromarines: A selective account of the potential of marine sponges, molluscs, soft corals and tunicates as a source of therapeutically important molecular structures / Jennifer Carroll and Phillip Crews -- Microorganisms: Their role in the discovery and development of medicines / Cedric Pearce, Peter Eckard, Iris Gruen-Wollny and Friedrich G. Hansske -- Advances in biological screening for lead discovery / Christian N. Parker, Johannes Ottl, Daniela Gabriel and Ji-Hu Zhang -- Advances in instrumentation, automation, dereplication and prefractionation / Tim S. Bugni, Mary Kay Harper, Malcolm W.B. McCulloch and Emily L. Whitson -- Natural product combinatorial biosynthesis: Promises and realities / Daniel W. Udwary -- A snapshot of natural product-derived compounds in late stage clinical development at the end of 2008 / Mark S. Butler -- From natural product to clinical trials: NPI-0052 (Salinosporamide A), a marine actinomycete-derived -- anticancer agent / Kin S. Lam, G. Kenneth Lloyd, Saskia T.C. Neuteboom, Michael A. Palladino, Kobi M. Sethna, Matthew A. Spear and Barbara C. Potts -- From natural product to clinical trials: Bevirimat, a plant-derived anti-AIDS drug / Keduo Qian, Theodore J. Nitz, Donglei Yu, Graham P. Allaway, Susan L. Morris-Natschke and Kuo-Hsiung Lee -- Daptomycin / Richard H. Baltz -- Micafungin / Akihiko Fujie, Shuichi Tawara and Seiji Hashimoto.

Natural Product Chemistry for Drug Discovery provides a comprehensive summary of where natural product chemistry is today in drug discovery. The book covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products. Natural products are once again considered important tools in the drug discovery toolbox. The authors are all experts in their respective fields of natural product chemistry.

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