Basic concepts of systems biology / Andrzej K. Konopka -- Understanding through modeling : a historical perspective and review of biochemical systems theory as a powerful tool for systems biology / Eberhard O. Voit and John H. Schwacke -- Thermostatics : a poster child of systems thinking / Peter Salamon, Anna Salamon, and Andrzej K. Konopka -- Friesian epistemology / Kelley L. Ross -- Reconsidering the notion of the organic / Robert E. Ulanowicz -- The metaphor of "chaos" / Wlodzimierz Klonowksi -- Biological complexity : an engineering perspective / Stephen W. Kercel -- The von Neumann's self-replicator and a critique of its misconceptions / Stephen W. Kercel -- The mathematical structure of thermodynamics / Peter Salamon [and others].

Systems Biology: Principles, Methods, and Concepts focuses on the technical practical aspects of modeling complex or organic general systems. It also provides in-depth coverage of modeling biochemical, thermodynamic, engineering, and ecological systems. Among other methods and concepts based in logic, computer science, and dynamical systems, it explores pragmatic techniques of General Systems Theory. This text presents biology as an autonomous science from the perspective of fundamental modeling techniques. A complete resource for anyone interested in biology as an exact science, it includes a comprehensive survey, review, and critique of concepts and methods in Systems Biology.