Includes Bibiliographical References and Index

Machine generated contents note: -- (preliminary) -- The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Healthspan and Lifespan -- Felipe Sierra -- Part One: Basic Mechanisms of Biological Aging -- An Overview of the Theory of Aging -- Steven Austad -- Cell Senescence -- Judith Campisi -- The Role of the Microenvironmental Niche in Declining Stem Cell Functions Associated with Biological Aging -- Nathan A. DeCarolis, Elizabeth D. Kirby, Tony Wyss-Coray, and Theo D. Palmer -- Biochemical Genetic Pathways that Modulate Aging in Multiple Species -- Alessandro Bitto, Adrienne M. Wang, Christopher F. Bennett, and Matt Kaeberlein -- Mitochondrial Dysfunction and Aging -- Douglas Wallace -- DNA Damage, DNA Repair, Aging, and Neurodegeneration -- Scott Maynard, Evandro Fei Fang, Morten Scheibye-Knudsen, Deborah L. Croteau, and Vilhelm A. Bohr -- How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend Initiative -- Fuki M. Hisama, Junko Oshima, and George M. Martin -- Dissecting the Mechanisms Underlying Successful Human Healthspan and Lifespan -- Sofiya Milman and Nir Barzilai -- Proteostasis and Aging -- Gordon Lithgow -- The Companion Dog as a Model for the Longevity Dividend -- Kate E. Creevy, Steven N. Austad, Jessica M. Hoffman, Dan G. O'Neill, -- and Daniel E.L. Promislow -- Part Two: Clinical and Translational Aspects of Aging -- The Translation of Aging Science into a Therapeutic Intervention -- James L. Kirkland -- Human Frailty -- Linda Fried -- The Aging Heart -- Ying Ann Chiao and Peter S. Rabinovitch -- Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond -- Dudley W. Lamming -- Metformin: A Hopeful Promise in the Aging Research -- Marta G. Novelle, Ahmed Ali, Carlos Dieguez, Michel Bernier, and Rafael de Cabo -- Part Three: Societal Implications of Delayed Aging -- Articulating the Case for the Longevity Dividend -- S. Jay Olshansky -- The Economic Promise of Delayed Aging -- Dana Goldman -- Past, Present, and Future of Healthy Life Expectancy -- Hiram Beltrán-Sánchez, Samir Soneji, and Eileen M. Crimmins -- Has the Rate of Human Aging Already Been Modified? -- S. Jay Olshansky.

"Aging affects us all and is characterized not only by increasing frailty but by increased susceptibility to conditions such as Alzheimer's, cardiovascular disease, and cancer. We are gaining an increasing understanding of the molecular mechanisms underlying aging, however, and uncovering clues to how life may be prolonged. This book examines the biological basis of aging and research into strategies that may extend lifespan"--