Systems Biology : Constraint based Reconstruction and Analysis (Record no. 296104)

MARC details
000 -LEADER
fixed length control field 02599nam a22001577a 4500
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781107038851
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Item number 570.15195 PAL-S
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Bernhard O. Palsson
245 ## - TITLE STATEMENT
Title Systems Biology : Constraint based Reconstruction and Analysis
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Cambridge University
Date of publication, distribution, etc. 2015
Place of publication, distribution, etc. Cambridge, United Kingdom
300 ## - PHYSICAL DESCRIPTION
Extent xviii, 531 pages ; 26 cm
505 ## - FORMATTED CONTENTS NOTE
Formatted contents note Introduction -- Part 1: Network Reconstruction -- Network Reconstruction: The Concept -- Network Reconstruction: The Process -- Metabolism in Escherichia coli -- Prokaryotes -- Eukaryotes -- Biochemical Reaction Networks -- Metastructures of Genomes -- Part 2: Mathematical Properties of Reconstructed Networks -- The Stoichiometric -- Simple Topological Network Properties -- Fundamental Network Properties -- Fundamental Network Properties -- Pathways -- Use of Pathway Vectors -- Randomized Sampling -- Part 3: Determining the Phenotypic Potential of Reconstructed Networks -- Dual Causality -- Functional States -- Constraints -- Optimization -- Determining Capabilities -- Equivalent States -- Distal Causation -- Part 4: Basic and Applied Uses -- Environmental Parameters -- Genetic Parameters -- Analysis of Omic Data -- Model-Driven Discovery -- Adaptive Laboratory Evolution -- Model-driven Design -- Part 5: Conceptual Foundations -- Teaching Systems Biology -- Epilogue.
520 ## - SUMMARY, ETC.
Summary, etc. Recent technological advances have enabled comprehensive determination of the molecular composition of living cells. The chemical interactions between many of these molecules are known, giving rise to genome-scale reconstructed biochemical reaction networks underlying cellular functions. Mathematical descriptions of the totality of these chemical interactions lead to genome-scale models that allow the computation of physiological functions. Reflecting these recent developments, this textbook explains how such quantitative and computable genotype-phenotype relationships are built using a genome-wide basis of information about the gene portfolio of a target organism. It describes how biological knowledge is assembled to reconstruct biochemical reaction networks, the formulation of computational models of biological functions, and how these models can be used to address key biological questions and enable predictive biology. Developed through extensive classroom use, the book is designed to provide students with a solid conceptual framework and an invaluable set of modeling tools and computational approaches. --Provided by publisher
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Systems biology. Biological models.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Book
Holdings
Withdrawn status Lost status Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
        Dept. of Computational Biology and Bioinformatics Dept. of Computational Biology and Bioinformatics Processing Center 18/01/2016   570.15195 PAL-S DCB2853 18/01/2016 19/07/2019 Book