Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery and Development (Record no. 295587)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02750nam a2200181Ia 4500 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0824742931 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.7 DRU |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Jae S Lee [ editor ] |
| 245 ## - TITLE STATEMENT | |
| Title | Drug Metabolizing Enzymes: Cytochrome P450 and Other Enzymes in Drug Discovery and Development |
| 250 ## - EDITION STATEMENT | |
| Edition statement | Special Indian Edition |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | CRC Press / Taylor & Francis |
| Date of publication, distribution, etc. | 2003 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | xx, 588 p. : ill ; 25 cm |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Dioxygen activation by cytochromes P450 - a role for multiple oxidants in the oxidation of substrates, Alfin D.N. Vaz; application of LC/MS, LC/NMR, NMR and stable isotopes in identifying and characterizing metabolites, A.E. Mutlib and John P. Shockcor; bioactivation, Jack Uetrecht; chemically reactive metabolites in drug discovery and development, Thomas A. Baillie; cytochrome P450 and its place in drug discovery and development, Dennis Smith; cytochrome P450 in laboratory animal species, Margit Spatzenegger, Stephanie L. Born and James R. Halpert; typical and atypical enzyme, Kinetics J. Brian Houston, Kathryn E. Kenworthy and Aleksandra Galetin; cytochrome P450 reaction phenotyping, Larry C. Wienkers and Jeffrey C. Stevens; drug-drug interactions and the cytochromes P450, Kenneth A. Bachmann, Barbara J. Ring and Steven A. Wrighton; CYP gene induction by xenobiotics and drugs, Jean-Marc Pascussi, Sabine Gerbal-Chaloin, Martine Daujat, Lionel Drocourt, Lydiane Pichard-Garcia, Marie-Jose Vilarem, Patrick Maurel, Sylvie Klieber, Francois Torreilles, Martine Bourrie, Francois Guillou and Gerard Fabre; cytochrome P450 pharmacogenetics, Robert L. Haining and Aiming Yu; role of intestinal cytochromes P450 in drug deposition, Mary F. Paine and Kenneth E. Thummel; prediction of hepatic clearance in humans from experimental animals and in vitro data, Masato Chiba, Yoshihiro Shibata, Hiroyuki Takahashi, Yasuyuki Ishii and Yuichi Sugiyama; non-P450 mediated oxidative metabolism of xenobiotics, Dieter Lang and Amit S. Kalgutkar; the role of sulfotransferases (SULTs) and UDP-glucuronosyltransferases (UGTs) in human drug clearance and bioactivation, Michael W.H. Coughtrie and Michael B. Fisher. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes - as well as parallel issues shaping the pharmaceutical industry - to promote the next generation of safer, more effective drugs. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drugs --Metabolism. Cytochrome P-450 Enzyme System. Enzymes. Preparations, Pharmaceutical. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | R Scott Obach; Michael B Fisher |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Book |
| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dept. of Computational Biology and Bioinformatics | Dept. of Computational Biology and Bioinformatics | Processing Center | 01/09/2015 | 615.7 DRU | DCB2413 | 01/09/2015 | 19/07/2019 | Book |