An introduction to systems biology : design principles of biological circuits /
Alon, Uri,
An introduction to systems biology : design principles of biological circuits / Uri Alon. - Second edition. - 324pages cm
Includes bibliographical references and index.
Part one: Network motifs -- Transcription networks basic concepts -- Autoregulation -- The feed forward loop -- Temporal programs and the global structure of transcription networks -- Positive feedback, bistability and memory -- How to build a biological oscillator -- Robustness -- Kinetic proofreading and conformational proofreading -- Part two: Robust signalling -- Chemotaxis -- Fold-change detection -- Dynamical compensation and mutal resistance in tissues -- Robust spatial patterning in development -- Part three: Optimality -- Optimal gene circuit design -- Multi-objective optimality in biology -- Modularity.
9781439837177 (pbk : alk. paper) 9781138490116 (hbk : alk. paper)
Systems biology.
Computational biology.
Biological systems
570.113 / ALO.A
An introduction to systems biology : design principles of biological circuits / Uri Alon. - Second edition. - 324pages cm
Includes bibliographical references and index.
Part one: Network motifs -- Transcription networks basic concepts -- Autoregulation -- The feed forward loop -- Temporal programs and the global structure of transcription networks -- Positive feedback, bistability and memory -- How to build a biological oscillator -- Robustness -- Kinetic proofreading and conformational proofreading -- Part two: Robust signalling -- Chemotaxis -- Fold-change detection -- Dynamical compensation and mutal resistance in tissues -- Robust spatial patterning in development -- Part three: Optimality -- Optimal gene circuit design -- Multi-objective optimality in biology -- Modularity.
9781439837177 (pbk : alk. paper) 9781138490116 (hbk : alk. paper)
Systems biology.
Computational biology.
Biological systems
570.113 / ALO.A